ABISS Edusepsis

Introducction

Title of the study: Evaluation of the effectiveness and efficiency of a multiple intervention aimed at improving early empirical antibiotic treatment for severe sepsis.

Acronym: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis)

General characteristics: prospective, multicenter study using a before-and-after design to evaluate a multiple intervention to translate knowledge into clinical practice.

Main objective: To evaluate the impact on mortality of a multiple intervention to translate knowledge about empirical antibiotic treatment for severe sepsis into clinical practice.

Secondary objectives:

• To evaluate the intervention’s impact on the time from the onset of sepsis to the administration of wide spectrum antibiotics.
• To evaluate the intervention’s impact on the percentage of patients that receive appropriate empirical antibiotic treatment for severe sepsis.
• To evaluate the efficiency of the intervention.
• To evaluate the long-term impact of the intervention.
• To determine whether there are discrepancies between perceived and actual compliance with the guidelines for the treatment of severe sepsis/septic shock.
• To determine the incidence of severe sepsis and septic shock in Spain.

Funded by a FIS grant from the Instituto Carlos III and carried out with the support of the SEMICYUC.

Principal Investigator: Ricard Ferrer